How to Get Rid of Mice Naturally. There are many control options for mice that have widely varying degrees of success. One secret to keep in mind is that your efforts to eradicate mice in your home is not a one-and-done proposition. Mice tend to move back outside in warmer weather but you can rest assured that in the fall when cooler temperatures return, they will also. This means that you must remain ever vigilant in denying paths of entry and ever watchful for signs of their presence. | How to