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Most people think tryptophan leads to serotonin, calmness, or sleepiness. But for some people, it takes a very different, and potentially dangerous, biochemical path. Dr. J explains how certain genetic variants in the TPH2 enzyme can divert tryptophan toward the kynurenine–quinolinic acid pathway. Quinolinic acid is neurotoxic and associated with increased risk for ALS, Alzheimer’s, brain ischemia, Huntington’s, and Parkinson’s. For those with TPH variants, tryptophan can trigger irritability, e
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