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When Muscle Relaxants Cause More Than Muscle Relaxation Most commonly prescribed muscle relaxants are centrally acting skeletal muscle relaxants. They do not act directly on muscle. They reduce muscle tone by depressing brainstem and spinal cord activity. 💊 Drugs in this class This includes cyclobenzaprine, carisoprodol, methocarbamol, metaxalone, chlorzoxazone, orphenadrine, tizanidine, and baclofen. 🧠 Drowsiness and brain fog These drugs are CNS depressants. Common effects include sedation,
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