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Depression is a mental state of low mood and aversion to activity.[3] It affects about 3.5% of the global population, or about 280 million people worldwide, as of 2020.[4] Depression affects a person's thoughts, behavior, feelings, and sense of well-being.[5]pleasure or joy that a person gets from certain experiences is reduced, and the afflicted person often experiences a loss of motivation or interest in those activities.[6] People with depression may experience sadness, feelings of dejection