The Dow topped 45,000 for the first time but Wall Street’s main indexes fell on Wednesday, with the Nasdaq leading declines as technology stocks slumped ahead of the Thanksgiving holiday. Meanwhile, investors focused on the Federal Reserve’s next move following an in-line inflation reading.

U.S. stocks rose Monday, with those benefiting the most from lower interest rates and a stronger economy leading the way. The S&P 500 climbed 0.3% to pull closer to its all-time high set two weeks ago.