Christian McCaffrey's injury against the Bills could be due to the heavy workload he received since returning to the 49ers.

The San Francisco 49ers are currently in last place in the division and in danger of missing the playoffs. The 49ers have ...

The San Francisco 49ers are moving forward without star running back Christian McCaffrey or backup Jordan Mason for the ...

49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury ...

Just when it seemed that San Francisco 49ers running back Christian McCaffrey was starting to find his rhythm, in a moment of ...

There are bad bye weeks, and then there are season-ruining bye weeks. This could be the latter for many teams needing a ...

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

Rookie fourth-round pick Isaac Guerendo seemed to be an afterthought in the San Francisco 49ers backfield with Christian ...

San Francisco 49ers offense. Scoring touchdowns in the red zone has been abysmal all season long for them and so has putti ...

The 2024 season has been a renaissance for running backs. After years of toiling away on middling teams, Philadelphia Eagles ...

The San Francisco 49ers’ 35-10 Week 13 loss to the Buffalo Bills was costly in more ways than one. Not only did it make San ...

The San Francisco 49ers' brutal battle against the injury bug continues to get worse, as they have lost their two main running backs — Christian ...