The EMBO Journal6h
A split intein and split luciferase-coupled system for detecting protein-protein interactions
The split intein-mediated protein ligation (SIMPL) system for detecting protein-protein interactions has been enhanced by ...
The EMBO Journal9h
Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs
Cholesterol restriction-mediated SREBP1 activation induces noncanonical type I IFNs, including IFN-ω and minor IFN-α subsets, ...
The EMBO Journal10d
Flagellar rotation facilitates the transfer of a bacterial conjugative plasmid
Unlike typical bacterial conjugation systems that are activated upon bacterial contact with solid surfaces, the pLS20 plasmid ...
The EMBO Journal9d
Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized primarily by the formation of heterotopic ...
The EMBO Journal8d
Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Retinoic acid (RA) signaling is a master ...
The EMBO Journal1d
The TRIM37 variant rs57141087 contributes to triple-negative breast cancer outcomes in Black women
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The risk variant rs57141087 is predominant in ...
The EMBO Journal23d
ZBTB48 is a priming factor regulating B-cell-specific CIITA expression
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The class-II transactivator (CIITA) is the ...
The EMBO Journal7d
Histone methyltransferases MLL2 and SETD1A/B play distinct roles in H3K4me3 deposition during the transition from totipotency to pluripotency
In early mammalian embryogenesis, a shift from non-canonical histone H3 lysine 4 trimethylation (H3K4me3) linked to transcriptional repression to canonical H3K4me3 indicating active promoters occurs ...
The EMBO Journal17d
Gpr54 deletion accelerates hair cycle and hair regeneration
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. GPR54, or KiSS-1R (Kisspeptin receptor), is ...
The EMBO Journal13d
Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chromatin remodeling is likely to be required ...
The EMBO Journal10d
Mechanisms of axoneme and centriole elimination in Naegleria gruberi
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The early branching eukaryote Naegleria ...