Kyle Shanahan’s 49ers will face Philip Rivers and the Colts next Monday night.

San Francisco 49ers quarterback Brock Purdy (13) runs the ball past Tennessee Titans linebacker Cedric Gray, left, during the ...

The 49ers square off against the Colts and their newly un-retired quarterback on Monday Night Football in Week 16.

San Francisco 49ers head coach Kyle Shanahan has made a shocking admission about the fallout with Brandon Aiyuk.

San Francisco 49ers coach Kyle Shanahan has shared some concerning news following the team's win over the Tennessee Titans.

The San Francisco 49ers collected a win on Sunday over the Tennessee Titans in Santa Clara, moving to 10-4 on the season and ...

The San Francisco 49ers beat the Tennessee Titans on Sunday, and in the locker room they celebrated their coach's birthday.

Brandon Aiyuk and the 49ers have kept their relationship long-distance as a divorce inevitably looms. One day after the club ...

The Brandon Aiyuk drama keeps getting weirder.

The San Francisco 49ers beat the Tennessee Titans on Sunday at Levi's Stadium. Here's what Kyle Shanahan had to say about his ...

The San Francisco 49ers are set to part ways with WR Brandon Aiyuk, and head coach Kyle Shanahan didn't mince words when ...

Brock Purdy threw three touchdown passes and the 49ers (10-4) cruised to a 37-24 win over the visiting Tennessee Titans (2-12 ...