When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...

R loops consist of RNA–DNA hybrids that accumulate at preferred regions all over the genome, such as pericentromeric DNA, telomeres, ribosomal DNA or transcription termination regions. R loops are an ...

Negative feedback is a universal control mechanism that lets a system's output throttle its input. If an engine revs up, negative feedback tapers its power source. But if the engine slows down, it ...

Human cells - like those of many other organisms - have developed mechanisms to protect us from cancer. Healthy cells produce a suite of molecules that stop harmful mutations from accumulating. The ...

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...

Supercoiling and looping can transmit mechanical stress along the DNA backbone that can promote the separation of the strands of the double helix at specific distant sites, exposing the DNA bases, ...