§ The review from David Allison and his colleagues highlights that while randomized controlled trials are powerful tools for examining cause-and-effect relationships, they are not immune to errors and ...

Interpreting data from randomized trials: the Scandinavian prostatectomy study illustrates two common errors Andrew Vickers Nature Clinical Practice Urology 2, 404–405 (2005) Cite this article ...

To improve the understanding of the appropriate design of phase II oncology clinical trials, we compared error rates in single-arm, historically controlled and randomized, concurrently controlled ...

Anyone who’s read my stuff with any regularity is acutely aware of my disdain for the way many observational studies are conducted and interpreted in health and nutrition research, as well as my ...

A randomized controlled trial aimed to determine whether providing information on patient risk for advanced colorectal neoplasia (ACN) to patients and providers affects colorectal cancer (CRC) ...

For AI tools making high-stakes clinical decisions, well-designed, prospective RCTs must be the gold standard.

Vaccine development can be a slow and uncertain matter—one often disparaged as ‘trial-and-error medicine.’ Is there no better way?

Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes. In this 6-month randomized, multicenter trial, patients with type 1 diabetes were ...