The 49ers square off against the Colts and their newly un-retired quarterback on Monday Night Football in Week 16.

Brandon Aiyuk and the 49ers have apparently kept their relationship long-distance as a divorce inevitably looms.

The San Francisco 49ers are set to part ways with WR Brandon Aiyuk, and head coach Kyle Shanahan didn't mince words when explaining the decision.

The 49ers placed Brandon Aiyuk on the reserve/left squad list on Saturday, ending the receiver's 2025 season before it could ever get off the ground.

San Francisco 49ers head coach Kyle Shanahan has made a shocking admission about the fallout with Brandon Aiyuk.

Kyle Shanahan provides key 49ers injury updates on Ricky Pearsall, Spencer Burford, Jacob Cowing and others after the win over the Titans.

San Francisco 49ers coach Kyle Shanahan called the decision to put missing receiver Brandon Aiyuk on a season-ending reserve list an easy one and it won't change what the team plans to do the rest of the season.

A day before the 49ers earned their 10th win of the year, it was reported that the team will officially be without wide receiver Brandon Aiyuk for the remainder of the 2025 season. The 49ers have placed Aiyuk on the reserve/left squad list, making him ineligible to return to the team this season.

San Francisco 49ers quarterback Brock Purdy looked like a basketball player with an impressive touchdown pass on Sunday.