Missing DNA replication step revealed in first image of pre-initiation complex

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
Nature

Mechanisms for licensing origins of DNA replication in eukaryotic cells

Fig. 4: The process of establishment of pre-RCs at an S. cerevisiae origin in which the B2 domain is separated from the A and B1 origin elements. This Review focuses on the first step in eukaryotic ...
Nature

The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication

Copy number control of DNA and centrosomes is essential for accurate genetic inheritance. DNA replication and centrosome duplication have been recognized as parallel key events for cell division. Here ...
Medical Xpress

One missing metabolic step can turn cancer's DNA-copying machinery into a lethal weakness

In turn, this slowed new DNA synthesis at replication forks, structures in which double strands of DNA separate to begin the copying process. The cells' attempt to restart the stalled replication fork ...
Phys.org

Researchers identify enzyme that prevents chromosome breaks during DNA copying

Researchers at The University of Texas Medical Branch (UTMB) have identified how a key enzyme called ATR protects DNA from breaking when cells copy damaged genetic material, a discovery that could ...