The precise temporal control of DNA replication and the coordinated activation of repair pathways are fundamental to genome stability. Eukaryotic chromosomes replicate in a defined programme during S ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

Genome stability during DNA replication depends on a coordinated network of enzymatic activities that ensure accurate duplication and mitigate threats arising from DNA lesions, replication impediments ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...