The epigenetic state of chromatin, gene activity, and chromosomal positions are interrelated. A research team from the IPK Leibniz Institute (IPK) and the Karlsruhe Institute of Technology (KIT) has ...

Chromosomal rearrangements, such as chromosome segment inversions, may affect the epigenetic landscape as well as gene expression. Different kinds of chromosome segment inversions have been found in ...

Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...

A new application of the CRISPR/Cas molecular scissors promises progress in crop cultivation. Researchers have succeeded in modifying the sequence of genes on a chromosome using CRISPR/Cas. For the ...

For decades, the Y chromosome—one of the two human sex chromosomes—has been notoriously challenging for the genomics community to sequence due to the complexity of its structure. Now, this elusive ...