A multi-institutional team of researchers led by Case Western Reserve University has identified a pattern of clustered genetic changes that appear to encourage growth of colorectal cancer tumors—a ...
Efforts to develop effective therapies for MYC-amplified Group 3 medulloblastoma (G3-MB) are hindered by an incomplete ...
Conceptual illustration showing how high transcriptional activity driven by super-enhancers can lead to DNA breaks at oncogenes. When these breaks are repaired inaccurately, they can give rise to ...
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Mapping 3D-super-enhancers with machine learning to pinpoint regulators of cell identity
Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...
Neuronal specification, expansion and differentiation are tightly regulated by the concerted actions of transcription and chromatin modifying factors that are recruited to regulatory elements in the ...
In a time when what defines gender is being questioned and discussed, a new study reveals that single changes in DNA make ...
A tumor-specific enhancer on extrachromosomal DNA drives MYC expression, revealing a new therapeutic target in high-risk ...
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