The etiology of sporadic Parkinson’s disease (PD) is complex and multifactorial, shaped by a dynamic interplay between genetic susceptibility and environmental exposures 1,2,3. While the majority of ...

A new analysis explores the genetic liability of psychiatric disorders using polygenic scores and recurrent copy number variants.

However, ES is not the first choice for detecting copy number variants (CNVs), which are typically deletions or duplications of DNA segments. CNVs cause a significant proportion of genetic disorders.

Non-invasive prenatal testing (NIPT) is a screening method that detects fetal chromosomal trisomies from cell-free DNA in maternal blood. Because NIPT uses whole-genome sequencing with next-generation ...

GWAS power plots. Power plots of current and future GWAS estimated using MiXeR (21), displaying the estimated proportion of SNP-heritability explained by genome-wide significant SNPs as a function of ...

Genetic inheritance may sound straightforward: One gene causes one trait or a specific illness. When doctors use genetics, it’s usually to try to identify a disease-causing gene to help guide ...

While non-invasive prenatal testing (NIPT) has revolutionised prenatal diagnostics by allowing the detection of a number of ...

A new study by UCLA Health published in Cell presents a major advancement in the future of personalized medicine by pinpointing new connections between people's genes, disease risk and medicine ...

Findings from 13 different studies analyzing 730 subjects to date in 2026 across multiple geographies underscore utility of OGM in key research areas including infertility, recurrent pregnancy loss, ...

Genome assemblies from 65 individuals, representing a variety of the world’s populations, are advancing the scientific exploration of complex genetic structural variation. Structural variations are ...

Bipolar disorder is a mental health condition characterized by extreme mood swings, with alternating periods of depression and manic episodes. Past research suggests that bipolar disorder has a strong ...