Saints running back Alvin Kamara hasn't played in a game since New Orleans' Week 12 showdown against the Atlanta Falcons. Kamara has dealt with knee and ankle injuries and missed the last two games against the Miami Dolphins and Tampa Bay Buccaneers.

The New Orleans Saints have remained in the top 3 for a while, but last week they posted a rare win, resulting in some movement. The Tennessee Titans also earned a victory, which was significant for the Saints, but going into Week 15, New Orleans now has the #5 overall pick in the draft.

Preview the Week 15 matchup between the Carolina Panthers and New Orleans Saints with predictions, odds, over/under, spread, betting lines and more.

One of the NFL's biggest surprises, Carolina (7-6) is coming off an impressive 31-28 win over the Los Angeles Rams. And while they are still on the outside looking in on the NFC playoff picture, the Panthers now control their own playoff destiny in the NFC South thanks to the Buccaneers ' loss to the Falcons on Thursday night.

The New Orleans Saints (3-10) host the Carolina Panthers (7-6) at Caesars Superdome on Sunday. The Saints won 17-7 in the first meeting in November. Here are the predictions from our staff for the second meeting between the NFC South teams.

Saints' offense faces a critical blow as star running back Alvin Kamara misses a third straight game, elevating rookie Devin Neal to lead the backfield.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 on a 50-35 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The New Orleans Saints have long been out of the running for the NFC South. But they still have a chance to impact the race.