Pharmacist Mark Mikhael has lost 50 pounds over the past 12 months. He no longer has diabetes and finds himself “at my ideal body weight,” with his cholesterol below 200 for the first time in 20 years.

The music world was shaken by news of Macy Gray's health scare, linked to the side effects of the popular weight-loss drug Ozempic.

The ubiquity of Ozempic has heightened the debate over body positivity and shaming of celebrities who use ldrugs to achieve dramatic results

The controversy around Ozempic started when celebrities, including Elon Musk, publicly endorsed its use for weight loss, sparking debates over its efficacy and safety outside its primary diabetes management role.

People taking the experimental drug amycretin were found to lose almost twice as much weight over a 12-week period as the average weight loss seen with semaglutide.

Ozempic is an FDA-approved medication for people who have type 2 diabetes. It’s often prescribed “off-label” for weight loss — when a drug is prescribed for something it’s not approved for.

Injectable prescription drugs that reduce appetite — like Ozempic, Saxenda and Mounjaro — have skyrocketed in popularity in recent years. Now, Cleveland Clinic researchers may have figured out which patients have the best odds of success.