With the approach of fall and cooler weather across the United States, officials say the risk posed by the H5N1 bird flu virus could rise — and they’re taking steps to prevent the creation of a hybrid flu virus that could more easily infect humans.

The Missouri case raised questions about the possibility of human-to-human bird flu transmission, but officials said there is no evidence of other people being infected.

The case is concerning because it's the first human case this year not tied to a known exposure to animals. Before now, all positive cases came after a person came into contact with infected dairy cows or poultry.