Influenza A: Understanding the Viral Life Cycle - PMC
WEBThe influenza virus life cycle can be divided into the following stages: entry into the host cell; entry of vRNPs into the nucleus; transcription and replication of the viral genome; export of the vRNPs from the nucleus; and assembly and …
Influenza A Virus Cell Entry, Replication, Virion Assembly and …
WEBJul 20, 2018 · To accomplish this goal, influenza A viruses (IAVs) utilize a combination of viral and cellular mechanisms to coordinate the transport of their proteins and the eight vRNA gene segments in and out of the cell.
Influenza A Virus Cell Entry, Replication, Virion Assembly and ... - PubMed
WEBJul 20, 2018 · The aim of this review is to present the current mechanistic understanding for how IAVs facilitate cell entry, replication, virion assembly, and intercellular movement, in an effort to highlight some of the unanswered questions regarding the coordination of the IAV infection process.
Entry of influenza A virus into host cells - ScienceDirect
WEBJun 1, 2021 · Influenza A viruses (IAV) are a major burden for human health and thus the topic of intense research efforts. The entry of IAV into host cells is of particular interest as early infection steps are the ideal target for intervention strategies. Here, we review recent key findings in the field of IAV entry.
A comprehensive map of the influenza A virus replication cycle
WEBOct 2, 2013 · A systematic understanding of influenza viral infection in host cells is needed to facilitate the identification of influential host response mechanisms and potential drug targets. We constructed a comprehensive map of the influenza A virus (‘IAV’) life cycle (‘FluMap’) by undertaking a literature-based, manual curation approach.
Influenza - Nature Reviews Disease Primers
WEBJun 28, 2018 · The influenza viruses can also express additional accessory viral proteins in infected cells, such as PB1–F2 and PA-x (influenza A), that participate in preventing host innate antiviral ...
Mapping of the influenza A virus genome RNA structure and ... - Cell …
WEBMar 26, 2024 · We investigated the IAV genome structure at single-nucleotide resolution by performing icSHAPE experiments on A549 cells infected with the influenza A/WSN/33 (WSN) virus.
Entry of influenza A virus into host cells - recent progress and ...
WEBThe entry of IAV into host cells is of particular interest as early infection steps are the ideal target for intervention strategies. Here, we review recent key findings in the field of IAV entry.
Influenza A Viruses: Understanding Human Host Determinants - Cell …
WEBOct 20, 2020 · Influenza viruses perform transcription and replication of their genome in the host cell nucleus, utilizing elements of the host cell transcription machinery. Thus, the heterotrimeric IAV polymerase complex (subunits PB2, PB1, and PA) requires interactions with numerous host cell factors for successful replication, and multiple mutations in the ...
Host and viral determinants of influenza A virus species specificity
WEBNov 28, 2018 · The host range of an influenza A virus is determined by species-specific interactions between virus and host cell factors. These include the ability to bind and enter cells, to replicate the...
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